IVERMECTIN 1% 50ml Ordinary plastic bottle

Ivermectin is widely used in gastrointestinal nematodes, pulmonary nematodes and parasitic arthropods of cattle, sheep, horses and pigs, intestinal nematodes of dogs, ear mites, scabies, heartworm and microfilariae, as well as gastrointestinal nematodes and ectoparasites of poultry.

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Ivermectin is a derivative of avermectin. William C. Campbell, the discoverer of avermectin, and Yoshimura won the 2015 Nobel Prize in physiology and medicine for their outstanding achievements in fighting river blindness and elephantiasis.

Ivermectin is a semi synthetic macrolide multicomponent antibiotic produced by Streptomyces avermitilis fermentation. It mainly contains ivermectin B1 (BLA + B1B) not less than 93%, of which BLA shall not be less than 85%.

Ivermectin B1 is 22,23-dihydroavermectin B1. Ivermectin is a new broad-spectrum, high-efficiency and low toxicity antibiotic antiparasitic drug. It has good repellent effect on internal and external parasites, especially nematodes and arthropods. But it has no effect on tapeworm, trematode and protozoa. The repellent effect of macrolide antiparasitic drugs on nematodes and arthropods lies in increasing the inhibitory transmitter of the insect body γ- The release of aminobutyric acid (GABA) and the opening of Cl ion channel controlled by glutamate enhance the permeability of nerve membrane to Cl, so as to block the transmission of nerve signals, and finally nerve paralysis, so that muscle cells lose their contractile ability, resulting in insect death.

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purpose
Ivermectin is widely used in gastrointestinal nematodes, pulmonary nematodes and parasitic arthropods of cattle, sheep, horses and pigs, intestinal nematodes of dogs, ear mites, scabies, heartworm and microfilariae, as well as gastrointestinal nematodes and ectoparasites of poultry.
(l) Ivermectin was administered orally or subcutaneously to cattle and sheep at the dose of 0.2mg/kg. The insect repellent rates of blood lance nematode, Oster nematode, Cooper nematode, round nematode (including round nematode), round nematode, supine mouth nematode, fine neck nematode, hairy head nematode, oesophagus nematode, reticulum, and sheep charbert nematode adults and stage 4 larvae were 97% ~ 100%. The above doses are also very effective for arthropods: such as fly maggots (cowhide fly, dermatodermis fly, sheep crazy fly), mites (bovine scabies mite, sheep itch mite) and lice (bovine palatal lice, bovine blood lice and sheep palatal lice), etc. Ivermectin was less effective on chewing lice (tricholice) and sheep ticks and flies.
Ivermectin is also very effective against ticks and flies breeding in feces. Although the drug can not immediately kill or dismember ticks, it can affect
Sound feeding, molting and oviposition, thereby reducing reproductive capacity. Animals were injected subcutaneously with 0.2mg/kg once or fed with low concentration every day
(0.01mg / kg) the above phenomenon was most obvious in ticks 5 days after treatment. A subcutaneous injection at the dose of 0.2mg/kg also has a certain control effect on the flies breeding in the feces. After 9 days of treatment, the larvae of facial fly and autumn housefly in the feces of cattle can not develop into adults. After 5 days, the reproduction of flies is greatly reduced due to the obstruction of pupal deformity and adult maturation process. After 4 weeks, the situation is similar for blood flies (disturbing blood flies).
(2) Oral administration of 0.2mg/kg ivermectin in horses and horses was highly effective (95% ~ 100%) on the adults and 4th stage larvae of the following large and small round nematodes, such as large round nematodes (common round nematode, horse round nematode, toothless round nematode), Ascaris lumbricoides (horse paraascaris), pinworms (horse pointed tail nematode), stomach worms (large mouth delassi nematode, flexible nematode) and intestinal nematodes (C. elegans, C. welchii), pulmonary nematodes (C. anseri), etc. for the three kinds of horsestomach fly maggots in the transitional or gastric residence period, the microfilariae of onchocerus and the third stage larvae of gastric nematodes causing skin damage, although the amount of 0.2mg/kg is also very limited, the best scheme is to use the above amount again one month later.
Of particular significance is that the recommended dose of ivermectin (0.2mg / kg) is about 99% effective in the treatment of mesenteric artery damage caused by the early and fourth stage larvae of common round nematode. Generally, the symptoms are significantly reduced after 2 days of treatment, and the damage symptoms are completely eliminated in about 28 days.
(3) Intramuscular injection of 0.3mg/kg ivermectin in pigs has broad-spectrum insect repellent activity on pigs, such as Ascaris lumbricoides, round nematode red, round nematode lamblia, pig hairy head nematode, oesophageal mouth nematode, round nematode, crown tail nematode, adult and immature worms. The elimination rate is 94% ~ 100%, and it has no effect on intestinal Trichinella (intramuscular) The above medication also has a good control effect on pig blood lice and pig scabies.
(4) There are special dosage forms for dogs and cats abroad [according to 6 ~ 12] μ G / kg) for the prevention and treatment of microfilaria infection of heartworm, which can be used for 50 years in China μ G / kg oral administration is effective in the treatment of microfilaria infection of heartworm (adults are ineffective). Clinical trials have confirmed that high-dose ivermectin is effective on a variety of parasites in dogs, such as 50% subcutaneous injection at a time μ G / kg vs. Caenorhabditis canis, Caenorhabditis brasiliensis and Caenorhabditis canis, 100 μ G / kg against whipworm canis, 200 μ G / kg has an excellent effect on the adult and fourth stage larvae of Toxocara canis. For Toxocara lion, it is 200 μ G / kg, the curative effect of subcutaneous injection is only 69%, while that of oral administration is 95%. This product is injected subcutaneously for one time, and it has no effect on the aerophilic Capillaria parasitized in the lungs of dogs (200%) μ G / kg), eustachia olgensis (400 μ g/kg)
It also has excellent expelling effect. Oral or subcutaneous injection of 200 μ G / kg, once again after two weeks, for intestinal fecal roundworm (No
The effective rate was 95% ~ 100%.
Ivermectin is also effective for some arthropod infections in dogs and cats. Dogs and cats are injected subcutaneously for 200 hours μ G / kg dose for two weeks
The infection of ear mite, scabies mite and canine lung acarid can be eliminated by another time. Press 300 μ G / kg, used twice (with an interval of 2 weeks)
It is also effective for chelonian mite infection. The best treatment for canine Demodex is 600 μ G / kg subcutaneous injection, with an interval of 7 days, for 5 times.
(5) For poultry nematodes such as Ascaris lumbricoides and closed Capillaria, as well as arthropods parasitic on poultry, such as knee mite (mutant knee mite), it is 200 ~ 300 μ G / kg oral or subcutaneous injection is effective, but this product is not effective against chicken heterothorn nematode.

(6) Reindeer infect reindeer with oedemagena tarandi according to the dosage of cattle (200 μ G / kg).

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